Takao Kondo




See also: kaiA, kaiC, Cyanobacterial clock proteins, and Circadian rhythm





































Takao Kondo
Born 1948
Kariya, Aichi
Residence
Nagoya, Japan
Nationality Japanese
Alma mater Nagoya University
Known for
Cyanobacterial clock proteins, kaiA, kaiC
Awards
Japan Academy Prize (2014)
Asahi Prize (2007)
Scientific career
Fields
Biology, Chronobiology
Institutions
Nagoya University
National Institute for Basic Biology


Takao Kondo (近藤 孝男, Kondō Takao) is a Japanese biologist and professor of biological science at Nagoya University in Nagoya, Japan. He is best known for reconstituting the circadian clock in vitro.




Contents






  • 1 Biography


  • 2 Research


  • 3 Honors


  • 4 References


  • 5 External links





Biography


Kondo was born in 1948 in Kariya, Aichi, Japan, and received his B.S. in 1970 and his Ph.D. in Biology in 1977 from Nagoya University.[1] He was appointed as an assistant professor at the National Institute for Basic Biology in Okazaki, Aichi, Japan in 1978.[1] Kondo began work as a visiting scholar at Harvard University in 1985, then continued his work abroad at Vanderbilt University between 1990 and 1991. It was at Vanderbilit University that Kondo began his research on the circadian clock of cyanobacteria.[2] Kondo returned to Nagoya University as a professor at the Graduate School of Science in 1995.[3] Kondo served as Dean of the School of Science from 2006 to 2009 and President of the Institute for Advanced Research of Nagoya University from 2007 to 2013. Kondo currently holds the title of Designated Professor and Professor Emeritus of Nagoya University.[4][5]



Research


Dr. Kondo is best known for his discoveries surrounding the molecular basis of the cyanobacteria circadian clock. Prior to Kondo's work in the late 1980s, controversy surrounding the existence of a biological clock in bacteria. Since bacteria divide rapidly and several times per day, it was thought that there was no necessity to evolve a biological clock in bacteria.[6]Promoter-trap and microarray analysis performed by Kondo in the cyanobacteria Synechococcus revealed that many, if not all, genes displayed a rhythmic, circadian component to their expression.[6] Kondo next employed a forward genetics approach and developed a luciferase reporter system to identify clock mutants in Synechococcus. Mutations that altered circadian behavior were grouped in a single region of the Synechococcus genome.[1] From this observation, Kondo discovered the gene cluster kaiABC as a circadian feedback process in cyanobacteria in 1998.[7] In 2002, Kondo demonstrated that kaiA-stimulated kaiC phosphorylation is necessary for circadian timing loops in cyanobacteria.[6] In 2005, Kondo succeeded in reconstituting the circadian oscillation of cyanobacterial kaiC phosphorylation in vitro.[8] Kondo's seminal 2005 discovery was the first example of a recapitulated biological rhythm in a test tube, mimicked rhythms observed in eukaryotic cells, and disproved the universal necessity of the transcription-translation autoregulatory feedback loop.[6] Kondo's characterization of kaiABC behavior provided a molecular mechanism by which proteins respond to changes in time and enabled the fields of bacterial genetics and quantitative biochemistry to aid investigation of the biological clock.[9]



Honors



  • 1980: American Society for Plant Physiologist[2]

  • 1990–present: Society of Research on Biological Rhythms[2]

  • 1995: Aschoff-Homna Prize [2]

  • 1999: Kihara Memorial Foundation Academic Award[1]

  • 1999-2005: Secretary-general, Japanese Society for Chronobiology[2]

  • 2005: Chunichi Prize [2]

  • 2006: Japanese Society of Botany Prize[2]

  • 2007: Asahi Prize[1]

  • 2007: Japanese Society for the Promotion of Science Prize[2]

  • 2011: Kihara Prize[2]

  • 2011: Medal with Purple Ribbon[2]

  • 2011–present: President, Japanese Society for Chronobiology[2]

  • 2014: Japan Academy Prize[2]

  • 2015: Gilbert Morgan Smith Medal [10]



References





  1. ^ abcde "生物時計のブラックボックスを開く" Biography of Dr. Takao Kondo (in Japanese)


  2. ^ abcdefghijkl "CDB Symposium 2015 : Takao Kondo". www.cdb.riken.jp. Retrieved 2017-04-12..mw-parser-output cite.citation{font-style:inherit}.mw-parser-output q{quotes:"""""""'""'"}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:inherit;padding:inherit}.mw-parser-output .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-limited a,.mw-parser-output .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{font-size:100%}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}


  3. ^ "Takao Kondo — Intercontinental Academia". intercontinental-academia.ubias.net. Retrieved 2017-04-12.


  4. ^ "Takao Kondo Curriculum Vitae" (PDF). srbr.org. Retrieved 2017-04-12.


  5. ^ "Kondo Takao Laboratory, Graduate School of Science, Division of Biological Science, Nagoya University". clock.bio.nagoya-u.ac.jp. Retrieved 2017-04-12.


  6. ^ abcd Pattanayak, Gopal; Rust, Michael J. (2014-04-01). "The cyanobacterial clock and metabolism". Current Opinion in Microbiology. 18: 90–95. doi:10.1016/j.mib.2014.02.010. ISSN 1879-0364. PMC 4068238. PMID 24667330.


  7. ^ Ishiura M, Kutsuna S, Aoki S, Iwasaki H, Andersson CR, Tanabe A, Golden SS, Johnson CH, Kondo T (1998). "Expression of a gene cluster kaiABC as a circadian feedback process in cyanobacteria". Science. 281 (5382): 1519–1523. doi:10.1126/science.281.5382.1519. PMID 9727980.


  8. ^ Nakajima M, Imai K, Ito H, Nishiwaki T, Murayama Y, Iwasaki H, Oyama T, Kondo T (2005). "Reconstitution of circadian oscillation of cyanobacterial KaiC phosphorylation in vitro". Science. 308: 414–415. doi:10.1126/science.1108451. PMID 15831759.


  9. ^ "Earth's daily rotation period encoded in an atomic-level protein structure". www.sciencedaily.com. Retrieved 2017-04-12.


  10. ^ "Gilbert Morgan Smith Medal". National Academy of Sciences. Retrieved 14 August 2015.




External links



  • Kondo Lab, Nagoya University

  • Japanese Society for Chronobiology









-

這個網誌中的熱門文章

Tangent Lines Diagram Along Smooth Curve

圖片
7 1 I am trying to replicate a diagram and have a minimal example. I don't know how to add additional tangents between the specified points and preserve smoothness. documentclass{article} usepackage{tikz} usetikzlibrary{calc,intersections} begin{document} begin{tikzpicture} % Axes draw [->, name path=x] (-1,0) -- (11,0) node [right] {$x$}; draw [->] (0,-1) -- (0,6) node [above] {$y$}; % Origin node at (0,0) [below left] {$0$}; % Points coordinate (start) at (1,-0.8); coordinate (c1) at (3,3); coordinate (c2) at (5.5,1.5); coordinate (c3) at (8,4); coordinate (end) at (10.5,-0.8); % show the points foreach n in {start,c1,c2,c3,end} fill [black] (n) circle (2pt) node [below] {}; % join the coordinates draw [thick,name path=curve] (start) to[out=70,in=180] (c1) to[out=0,in=180]
閱讀完整內容

Yusuf al-Mu'taman ibn Hud

圖片
Main article: Taifa of Zaragoza Al-Mu'taman Ruler of Zaragoza Reign 1081–1085 Predecessor Ahmad al-Muqtadir Successor Al-Mustain II Born Zaragoza Died 1085 Full name Yusuf ibn Ahmad al-Mu'taman ibn Hūd House Banu Hud Yusuf ibn Ahmad al-Mu'taman ibn Hūd (Arabic: المؤتمن بالله يوسف إبن أحمد إبن هود ‎, al-Mutaman bi l-Lah , died c. 1085) was the third king of the Banu Hud dynasty who ruled over the Taifa of Zaragoza from 1081 to 1085. Yusuf al-Mutaman reigned during the height of power of Muslim Zaragoza , following the thriving period of his father Ahmad al-Muqtadir. He continued his father's efforts and created around him a court of intellectuals, living in the beautiful palace of Aljafería, nicknamed as "the palace of joy". Al-Mu'taman was also a scholarly king and a patron of science, philosophy and arts. As an example of a wise king, he knew astrology, philosophy, and especially mathematics, a discipline in which
閱讀完整內容

Zucchini

圖片
This article is about the vegetable. For other uses, see Zucchini (disambiguation). Zucchini (courgette) A striped and a uniform color zucchini Genus Cucurbita Species Cucurbita pepo Origin 19th century northern Italy The zucchini ( / z uː ˈ k iː n i / , American English) or courgette ( / k ʊər ˈ ʒ ɛ t / , British English) is a summer squash which can reach nearly 1 metre (100 cm; 39 in) in length, but is usually harvested when still immature at about 15 to 25 cm (6 to 10 in). [1] A zucchini is a thin-skinned cultivar of what in Britain and Ireland is referred to as a marrow. [2] [3] In South Africa, a zucchini is known as a baby marrow. Along with certain other squashes and pumpkins, the zucchini belongs to the species Cucurbita pepo . It can be dark or light green. A related hybrid, the golden zucchini, is a deep yellow or orange color. [4] In a culinary context, the zucchini is treated as a vegetable; it is usually cooked and presented as a savory dish o
閱讀完整內容