Cefmetazole












































































Cefmetazole
Cefmetazole.svg
Clinical data

AHFS/Drugs.com
 International Drug Names
MedlinePlus a601206
ATC code

  • J01DC09 (WHO)
Identifiers
CAS Number

  • 56796-20-4 ☑Y

PubChem CID
  • 42008
DrugBank

  • DB00274 ☑Y
ChemSpider

  • 38311 ☑Y
UNII
  • 3J962UJT8H
KEGG

  • D00910 ☑Y
ChEBI

  • CHEBI:3489 ☑Y
ChEMBL

  • ChEMBL1201195 ☒N
ECHA InfoCard
100.054.877 Edit this at Wikidata
Chemical and physical data
Formula
C15H17N7O5S3
Molar mass 471.538 g/mol
3D model (JSmol)
  • Interactive image

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 ☒N☑Y (what is this?)
  (verify)

Cefmetazole is a cephamycin antibiotic, usually grouped with the second-generation cephalosporins.



Adverse effects


The chemical structure of cefmetazole, like that of several other cephalosporins, contains an N-methylthiotetrazole (NMTT or 1-MTT) side chain. As the antibiotic is broken down in the body, it releases free NMTT, which can cause hypoprothrombinemia (likely due to inhibition of the enzyme vitamin K epoxide reductase) and a reaction with ethanol similar to that produced by disulfiram, due to inhibition of aldehyde dehydrogenase.[1]



Spectrum of bacterial susceptibility


Cefmetazole is a broad-spectrum cephalosporin antimicrobial and has been effective in treating bacteria responsible for causing urinary tract and skin infections. The following represents MIC susceptibility data for a few medically significant microorganisms.




  • Bacteroides fragilis: 0.06 - >256 µg/ml


  • Clostridium difficile: 8 - >128 µg/ml


  • Staphylococcus aureus: 0.5 - 256 µg/ml (includes MRSA)


[2]



References





  1. ^ Stork CM (2006). "Antibiotics, antifungals, and antivirals". In Nelson LH, Flomenbaum N, Goldfrank LR, Hoffman RL, Howland MD, Lewin NA. Goldfrank's toxicologic emergencies. New York: McGraw-Hill. p. 847. ISBN 0-07-143763-0. Retrieved 2009-07-03..mw-parser-output cite.citation{font-style:inherit}.mw-parser-output q{quotes:"""""""'""'"}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:inherit;padding:inherit}.mw-parser-output .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-limited a,.mw-parser-output .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{font-size:100%}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}


  2. ^ http://www.toku-e.com/Assets/MIC/Cefmetazole%20free%20acid.pdf










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